In allergic diseases (e.g. allergic asthma, atopic and contact eczema) the immune system reacts towards harmless environmental substances, such as pollen-derived proteins or the proteins from dust mites. In autoimmune diseases, such as in lupus erythematosus or multiple sclerosis, healthy human tissue is attacked by own immune system. Thus, both disease groups are mediated by disturbed immunotolerance. Moreover, in the last years it has become apparent that allergies can by complicated by autoimmune responses that result in autoallergies.
Currently, we are analyzing the impact of autoreactive Immunoglobulin E (IgE) antibodies in:
Atopic dermatitis, asthma and urticaria
Discover what is the role of autoreactive IgE antibodies in autoallergic diseases